Research Highlights
Welcome to the NeuroNest Research Highlights page! Here, we dive into the fascinating world of neuroscience and psychology, bringing you the latest discoveries and insights. We are committed to providing fresh content every week so check back regularly for the latest insights, lab spotlights, and field notes from NeuroNest.
Lab Spotlights: Each month, we shine a light on a captivating neuroscience or psychology lab, whether it's a local gem or a global leader. Discover their ongoing research and groundbreaking work.
Student Work: We accept and showcase student-led projects, senior theses, and student research!
Field Notes: Stay up-to-date with concise, accessible summaries of new research papers and scientific breakthroughs in neuroscience and psychology. We deliver the key information you need, without the jargon.
Figure 2. Dopamine Pathway Alterations in Addiction .
Figure 4. Neuroimmune Interaction In Addiction
Field Notes: New Frontiers in Addiction Treatment
Addiction is a complex brain disorder that changes how the brain’s reward, motivation, and control systems work. It’s not just about willpower—addiction rewires the brain at a molecular level, making it hard to quit. Scientists are now exploring new treatments that target these brain changes directly. Gene therapies like CRISPR-Cas9 aim to edit genes linked to addiction, while drugs called HDAC and DNMT inhibitors may help reactivate genes that addiction has turned off. Another important area is neuroimmune modulation: chronic drug use causes brain inflammation, which worsens addiction. Anti-inflammatory drugs and vaccines that block drugs from reaching the brain show promise in reducing cravings. Despite these advances, treating addiction remains difficult because it involves many factors, including genetics and environment. Emerging technologies like brain stimulation and digital health tools may help improve recovery in the future. Overall, these new approaches offer hope for more personalized and effective addiction treatments beyond just relying on willpower.
Table 3. Gene Therapy and Epigenetic Modulation Approaches in Addiction Treatment .
Aejeeliyah Yousuf. (2025). Neuroscience of Addiction Molecular Mechanisms and Potential Therapeutic Targets. Middle East Journal of Pure and Applied Sciences (MEJPAS), 1(1), 55-63. https://mideastjournals.com/index.php/mejpas/article/view/12
Title: Neuroscience of Addiction Molecular Mechanisms and Potential Therapeutic Targets
Field Notes: Trauma, Addiction, and the Quiet Power of Mindfulness
This study investigated how Adverse Childhood Experiences (ACEs) affect individuals with Opioid Use Disorder (OUD), particularly in relation to pain interference (how much pain disrupts daily life). People with high ACEs tend to experience more intense psychological symptoms and often respond poorly to standard treatments. The researchers examined whether mindfulness-based interventions (MBIs), which promote self-awareness and emotional regulation, could help this population by targeting two psychological processes linked to trauma and chronic pain: self-critical rumination (SCR), or the tendency to dwell on self-directed negative thoughts, and pain catastrophizing, which involves exaggerating the severity or impact of pain. They hypothesized that ACEs lead to increased SCR, which in turn increases pain catastrophizing and worsens pain interference. Using data from a 24-week clinical trial comparing a trauma-informed online mindfulness program (M-ROCC) to an active recovery support group, they found that ACEs influenced treatment outcomes only in the MBI group. In that group, reductions in SCR mediated reductions in pain catastrophizing, supporting the idea that MBIs can interrupt harmful psychological cycles in those with high ACEs. No significant group-level differences emerged, but the findings suggest that MBIs may offer particular benefits for individuals with trauma histories by addressing specific thought patterns that worsen pain and psychological distress.
Figure 1: Different temporal paths of symptom changes in the (A) M-ROCC and (B) active control group
Figure 2: Correlations between ACE scores and ΔSCRS at week 8 in the M-ROCC treatment arm.
Joss, D., Rosansky, J., Gardiner, P., Edwards, R. R., Weiss, R. D., Napadow, V., & Schuman-Olivier, Z. (2025). Modulating mechanisms of adverse childhood experiences in a mindfulness-based intervention: Preliminary insights from an opioid use disorder study. Frontiers in Psychology, 16. https://doi.org/10.3389/fpsyg.2025.1529106
Title: Modulating mechanisms of adverse childhood experiences in a mindfulness-based intervention: preliminary insights from an opiod use disorder study
Student Work: Hyperventilation and Blood Alkalization Effect on Seizures in a Mouse Model of Absence Epilepsy
Ashley Mchugh
B.S. in Cognitive Science, University of Virginia
Absence epilepsy is a childhood neurological disorder marked by brief lapses in consciousness, often seen as staring spells. These seizures can be triggered by hyperventilation, but the underlying mechanisms are not well understood. One theory suggests blood alkalization from hyperventilation may be the cause. This study tested whether hyperventilation induces spike-wave discharges (SWDs), the brain activity signature of absence seizures, in C3H/HeJ mice, a model of the disorder. EEG headsets were used to monitor SWDs during experiments using two setups: (1) a head-fixed rig with hypoxic gas delivery via nose cone, and (2) plethysmography chambers that better induced hyperventilation by adjusting gas composition. An additional experiment used acetazolamide, a drug that lowers blood pH, to test whether reversing alkalization affects SWDs. The head-fixed setup failed to reliably trigger hyperventilation, showing no change in SWDs. In contrast, the plethysmography chambers effectively induced hyperventilation, leading to increased breathing rate and SWD activity. The acetazolamide results were inconclusive due to small sample size and high variability.
Student Work: Neural Mechanisms of Choreographic Memory: An EEG Study on Dance Learning and Recall
While dance is fundamental to human culture, its neural basis is underexplored. This study examined dance learning and recall using EEG. Fifteen dancers watched seven short clips while wearing an EEG cap, followed by 30-second mental imagery periods. After all the clips, they performed the choreography from memory. Alpha power increased significantly during imagery, especially in posterior regions, suggesting its role in memory recall and motor planning. A strong positive correlation showed that individuals with higher alpha power during video watching also had higher alpha power during imagery. These findings highlight EEG’s potential to reveal choreographic memory processes. Future research should explore marking, verbal rehearsal, and other memory-enhancing techniques in dance learning.
Figure 2: Topological maps of mean alpha power during a) video watching and b) mental imagery conditions. c) The plot highlights electrodes with significant differences (p < 0.05) between conditions (PO4 and P8).
Figure 4: Comparison of Alpha Power During Video Watching and Mental Imagery Conditions. a) Raincloud plot. Individual participants’ alpha power values are plotted, with grey lines connecting paired values. Most lines trend upward, indicating higher alpha power during Mental Imagery. b) Boxplots. The median, interquartile range, and whiskers are displayed for each condition. Higher and more variable alpha power is evident during Mental Imagery. c) Density Plots. Overlapping distributions show a rightward shift for Mental Imagery, reflecting increased alpha power compared to Video Watching.
Field Notes: ipER, Borderline Personality Disorder and Memory
Krause-Utz, A., Saygin, M., Podbylska, M., Chatzaki, E., la Rosa, B., & Lis, S. (2025). Interpersonal emotion regulation, borderline personality disorder symptoms, and working memory during social-affective distraction. Personality Disorders: Theory, Research, and Treatment, 16(3), 210–222. https://doi.org/10.1037/per0000722
Title: Interpersonal Emotion Regulation, Borderline Personality Disorder Symptoms, and Working Memory During Social-Affective Distraction
This paper explores how emotion regulation (ER), particularly interpersonal emotion regulation (ipER), is influenced by context, especially in social situations where emotions signal mental states and secure support. While most research has focused on internal ER strategies, recent studies highlight the importance of ipER, where emotions are regulated through social interactions. Hofmann et al. (2016) identified four key ipER strategies: enhancing positive affect, perspective-taking, social modeling, and soothing.
In Borderline Personality Disorder (BPD), which involves heightened emotional sensitivity and difficulty returning to baseline emotions, individuals struggle with ipER, particularly under relational stress. People with BPD often use interpersonal support ineffectively, engage in maladaptive behaviors, and report lower emotion regulation efficacy. Cognitive deficits, especially in attention and working memory (WM), may hinder ipER by affecting responses to social-emotional cues.
The study found that poorer WM performance was linked to reduced use of ipER strategies, particularly enhancing positive affect. Higher BPD symptom severity also predicted less frequent use of ipER strategies. Working memory deficits partially explained these difficulties, suggesting emotional inflexibility, rather than the complete absence of strategies, as a core issue in BPD.
Field Notes: The Heart's Own "Little Brain"
This 2024 update highlights how neuroscience is becoming a game-changer in treating heart disease. It explores the role of the autonomic nervous system (ANS), the part of the nervous system that automatically controls things like heart rate and blood pressure, and how its dysfunction can contribute to serious cardiac conditions, including arrhythmias and sudden cardiac death.
What’s especially exciting is the paper’s focus on new therapies that use neuroscience to actually modulate heart function. For example, vagus nerve stimulation, spinal cord stimulation, and other neuromodulation strategies are being developed to "reset" how the brain and heart communicate. These treatments aim to calm overactive sympathetic responses (the "fight or flight" system) or strengthen weakened parasympathetic signals (the "rest and digest" system), offering more precise, personalized treatment options.
In short: the future of heart health might just be through the nervous system!
Figure 1: Organization of cardiac neural control
Ajijola, O. A., Aksu, T., Arora, R., Biaggioni, I., Chen, P., De Ferrari, G., Dusi, V., Fudim, M., Goldberger, J. J., Green, A. L., Herring, N., Khalsa, S. S., Kumar, R., Lakatta, E., Mehra, R., Meyer, C., Po, S., Stavrakis, S., Somers, V. K., … Shivkumar, K. (2025). Clinical neurocardiology: Defining the value of neuroscience‐based Cardiovascular therapeutics – 2024 update. The Journal of Physiology, 603(7), 1781–1839. https://doi.org/10.1113/jp284741
Title: Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics – 2024 update
Field Notes: Can Parenting Shape Personality Into Adulthood?
A new longitudinal twin study suggests that affectionate parenting during childhood (ages 5-10) may positively shape personality traits like openness, conscientiousness, and agreeableness by the time teens reach adulthood at age 18. Using over 2,000 identical twins in the UK, researchers found that even small differences in parenting between twins led to measurable differences in these traits despite shared genetics and environment. While effects were modest, the findings support the idea that positive parenting has lasting, meaningful impacts on who we become, with potential for public policy and early intervention.
Wertz J, Moffitt TE, Blangis F, Ambler A, Arseneault L, Danese A, Fisher HL, Caspi A. Parenting in childhood predicts personality in early adulthood: A longitudinal twin-differences study. Am Psychol. 2025 Apr 17. doi: 10.1037/amp0001508. Epub ahead of print. PMID: 40244963.
Title: Parenting in childhood predicts personality in early adulthood: A longitudinal twin-differences study
Field Notes: GABA and Psychosis - It’s Not Just About One Brain Region
Disruptions in the GABA system- a key inhibitory neurotransmitter- may play a role in schizophrenia and early psychosis. While past studies have found reduced GABAergic neurons and receptor levels in the hippocampus, this new PET imaging study reveals something deeper: it's not just about changes in one brain region. Instead, individuals with first-episode psychosis or at high risk for psychosis show altered network-level organization of a specific GABA receptor (GABA A α5), even though the overall amount of this receptor in the hippocampus isn't significantly different from healthy controls. This suggests that psychosis may involve system-wide dysregulation in how GABA A α5 receptors are coordinated across the brain, not just local deficits.
Figure 1: [11C]Ro15-4513 binding in the hippocampus between groups.
Figure 2: Pertubation covariance z-score statistics.
Lukow, P. B., Schubert, J. J., Severino, M., Knight, S. R., Kiemes, A., Livingston, N. R., Davies, J., de Micheli, A., Spencer, T. J., Fusar-Poli, P., Haege, B., Vorontsova, N., Donocik, J., Rabiner, E. A., Grace, A. A., Williams, S. C., McGuire, P., Veronese, M., Turkheimer, F. E., & Modinos, G. (2025). GABAaReceptor Availability in Clinical High-Risk and First-Episode Psychosis: A [11C]RO15-4513 Positron Emission Tomography Study. https://doi.org/10.1101/2025.02.27.25322861
Title: GABA A receptor availability in clinical high-risk and first-episode psychosis: a [11C]Ro15-4513 positron emission tomography study
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